Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronavirusesArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] Analysis common cold Coronaviruses Compound COVID-19 COVID-19 therapeutics cytotoxicity effective gene expression profile globe Heat shock homoharringtonine host cell response host response in silico in vitro modulating other coronavirus pandemic pathway Prevent provided reported SARS-CoV-2 SARS-CoV-2 biology screened severe symptoms tanespimycin target tested unique Vaccine viral infection [DOI] 10.1038/s41598-022-21984-w PMC 바로가기
The naturally-derived alkaloids as a potential treatment for COVID-19: A scoping reviewCOVID-19의 잠재적 치료제로서의 천연 유래 알칼로이드: 범위 검토Review Published on 2022-07-012022-09-11 Journal: Phytotherapy research : PTR [Category] COVID19(2023년), SARS, 치료제, [키워드] activities acute respiratory syndrome coronavirus alkaloids Anti-inflammatory Antiviral applicability assessments berberine binding energy caused cephaeline clinical trial clinical trials Colchicine coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 database described Effects eligible Emetine Ergotamine high mortality rate homoharringtonine in silico in vitro Inflammatory marker inflammatory markers inhibit knowledge lycorine medicinal plant narciclasine natural product. new treatment strategy observational studies papaverine pharmacological plant Potential treatment Protein target protein targets Quinine reduce respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 target proteins Therapeutic compounds Transmissibility treating COVID-19 variety was performed [DOI] 10.1002/ptr.7442 PMC 바로가기 [Article Type] Review
A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entryTMPRSS2 발현을 위한 고처리량 스크린으로 SARS-CoV-2 진입을 제한할 수 있는 FDA 승인 화합물 식별Article Published on 2021-06-232022-09-10 Journal: Nature Communications [Category] MERS, SARS, 비임상, [키워드] 2019-nCoV ACE2 breath Cell cell entry cell surface receptor clinical trial Compound compounds Concentration concentrations coronavirus COVID-19 disease COVID-19 infection DCAF1 DDB1 Degradation dependent on drug E3 ubiquitin ligase Effect entry of SARS-CoV-2 epithelial cells expression global pandemic halofuginone help High-throughput screening homoharringtonine Host host protease host proteases human clinical trial human clinical trials Human plasma identify in vitro library limit lung epithelial cell modulate pathogenic coronavirus pharmacokinetic data proteasome Protein reduce reducing responsible SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 glycoprotein SARS-COV-2 infection Screen Serine serine protease serine protease TMPRSS2 small molecule Small molecules spike stability surface expression surface receptor the cell TMPRSS2 TMPRSS2 expression TMPRSS2 level TMPRSS2 levels TMPRSS2 protein [DOI] 10.1038/s41467-021-24156-y PMC 바로가기 [Article Type] Article
Identification and Tracking of Antiviral Drug CombinationsArticle Published on 2020-10-182022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] A549 cells acute respiratory syndrome addition Antiviral antiviral drug antiviral drug combinations antivirals broad-spectrum antivirals calu-3 cells cells Combination convalescent serum coronavirus cycloheximide demonstrated developmental drug Efficacy EIDD-2801 epithelial HCV hepatitis C virus HIV-1 HIV-1 infection homoharringtonine Human immunodeficiency virus human lung identification identify in vitro Infection infections monensin monotherapy neutralizing antibody Prevent purified reduced Remdesivir resource SARS-CoV-2 synergistic synergy therapy Toxicity treat treatment for HIV viral strain virus [DOI] 10.3390/v12101178 PMC 바로가기 [Article Type] Article
Repurposing old drugs as antiviral agents for coronavirusesResearch article Published on 2020-08-012022-10-05 Journal: Biomedical journal [Category] SARS, 신약개발, 치료제, [키워드] active against acute respiratory syndrome adverse effect Anti-viral antiviral agent approved Cell Chloroquine Clinical use Compound Concentration Control coronavirus coronavirus coronavirus disease Coronavirus-2 COVID-19 COVID-19 patients Cytopathic effect dosing schedule drug Drug repurpose EC50 EC50 value HCoV-OC43 HCT-8 cell HCT-8 cells homoharringtonine human coronavirus OC43 humans indication inhibitory activity New nucleocapsid protein pandemic profile proliferation repurposing Result Salinomycin SARS-CoV-2 SARS-CoV-2 drug screened staining therapeutic option Toxicity treating COVID-19 viability were measured [DOI] 10.1016/j.bj.2020.05.003 [Article Type] Research article
Turning the Tide: Natural Products and Natural-Product-Inspired Chemicals as Potential Counters to SARS-CoV-2 InfectionPharmacology Published on 2020-07-022022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome anti-SARS-CoV-2 antiviral activities Antiviral agents cause Chemical coronavirus coronavirus disease counter COVID-19 drug Ebselen effective EIDD-2801 GS-5734 highly pathogenic homoharringtonine Ivermectin natural natural products natural-product-inspired Potential potential anti-SARSCoV-2 agents product public health Research Safe SARS-CoV-2 SARS-COV-2 infection small molecule Turning [DOI] 10.3389/fphar.2020.01013 PMC 바로가기 [Article Type] Pharmacology
Potential Antiviral Options against SARS-CoV-2 InfectionArticle Published on 2020-06-132022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] antiviral drug antiviral drug combinations antivirals broad-spectrum antiviral broad-spectrum antivirals Combination costly disseminate exhibited highest homoharringtonine Infection knowledge monoclonal antibody Neutralization assay option Potential recovered patient Respiratory Coronavirus Salinomycin SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 strain SARS-CoV-2-infected patients screened sera synergy the SARS-CoV-2 time-consuming Treatment treatments of COVID-19 United Nation Vaccines Vero-E6 cell Vero-E6 cells website WHO World Health Organization [DOI] 10.3390/v12060642 PMC 바로가기 [Article Type] Article
Three kinds of treatment with Homoharringtonine, Hydroxychloroquine or shRNA and their combination against coronavirus PEDV in vitroResearch Published on 2020-06-032022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] antiviral activity Antiviral agents antiviral effects antiviral strategy caused Combination combination treatment conserved contribute coronavirus coronavirus effective epidemic diarrhea exhibited family Coronaviridae HCQ heptad repeat homoharringtonine Hydroxychloroquine in vitro Infection information inhibitor PEDV reduced Result short hairpin RNA TCID Treatment virus virus titer [DOI] 10.1186/s12985-020-01342-w PMC 바로가기 [Article Type] Research
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitroArticle Published on 2020-04-032023-07-02 Journal: Antiviral Research [Category] SARS, [키워드] Abstract COVID-19 Emetine homoharringtonine Lopinavir Remdesivir Ritonavir [DOI] 10.1016/j.antiviral.2020.104786 PMC 바로가기 [Article Type] Article
Anti-varicella-zoster virus activity of cephalotaxine esters in vitroArticle Published on 2019-01-012023-05-31 Journal: Journal of microbiology (Seoul, Korea) [Category] 두창, 수두, 홍역, [키워드] Antiviral harringtonine homoharringtonine Varicella zoster virus. [DOI] 10.1007/s12275-019-8514-z PMC 바로가기